EXELIXIS SELECTS SWEDISH ORPHAN BIOVITRUM AB AS COMETRIQ (TM) EUROPEAN DISTRIBUTOR FOR MEDULLARY THYROID CANCER

Contact:
Charles Butler
Vice President, Investor Relations and Corporate Communications
Exelixis, Inc.
(650) 837-7277
cbutler@exelixis.com

Anders Edvell
Vice President, Sobi Partner Products, Sobi
+46 8 697 2000
anders.edvell@sobi.com

Jörgen Winroth
Vice President, Investor Relations, Sobi
+46 8 697 3427
jorgen.winroth@sobi.com

South San Francisco, CA and Stockholm, Sweden - February 22, 2013 - Exelixis,
Inc. (NASDAQ:EXEL) and Swedish Orphan Biovitrum (Sobi) (STO: SOBI) today
announced that they have entered into a three-year agreement to support the
distribution and commercialization of COMETRIQ(TM) (cabozantinib) for metastatic
medullary thyroid cancer (MTC) in the European Union (EU) and potentially other
countries.  No other indication is covered by this agreement, and Exelixis
maintains full commercial rights for COMETRIQ in MTC outside the covered
territory and for all other indications on a global basis. On November
29, 2012, Exelixis announced that the European Medicines Agency (EMA) accepted
for review the Marketing Authorization Application (MAA) for COMETRIQ for the
proposed indication of treatment of progressive, unresectable, locally advanced,
or metastatic MTC.

"We are pleased to be working with Sobi to distribute and commercialize COMETRIQ
for MTC in the EU, while at the same time maintaining commercial rights for all
other oncology indications on a global basis," said Michael M. Morrissey, Ph.D.,
president and chief executive officer of Exelixis. "By contracting with Sobi for
distribution and commercialization services, we believe we will be able to
realize the full value of the MTC opportunity in Europe and potentially other
regions without the need for a large-scale investment in sales and marketing
infrastructure. This strategy is consistent with our commitment to match our
commercialization investments with the potential value of each opportunity. We
look forward to working with Sobi, which has proven sales and marketing
expertise in Europe, to make COMETRIQ available under a Named Patient Use (NPU)
program and then more broadly assuming EMA approval."

"COMETRIQ is an important potential new treatment option for patients with
metastatic MTC," said Anders Edvell, Vice President and Head of Partner Products
at Sobi . "We look forward to leveraging our years of specialized expertise in
these markets to support the COMETRIQ NPU program and, upon EMA approval, its
commercial development in MTC."

Under the terms of the agreement, Exelixis will continue to be responsible for
regulatory approvals in the covered territory.  Sobi will serve as the exclusive
distributor of COMETRIQ in the covered territory where applicable for NPU
requests, and will, if approved by the EMA, promote, market, and sell COMETRIQ
for MTC in the covered territory. Exelixis' payments to Sobi include certain
pre-determined fixed fees as well as potential performance based milestones
related to the commercialization of the product in the covered territory.
Exelixis will book revenues based on product sold to Sobi.  Exelixis has the
ability to terminate the agreement at will at any time upon payment of certain
pre-determined fees.

About Named Patient Use (NPU) Programs
A named patient use (NPU) program provides access to unapproved drugs for a
single patient or group of patients in a particular country. Products offered
through NPU programs can be investigational (e.g. still in clinical studies) or
approved in one country but not yet approved in the patients home country.
Regulations governing NPU programs vary by country but companies offering
products through NPU can sometimes charge for the product being administered.

About COMETRIQ(TM)
COMETRIQ (cabozantinib) inhibits the activity of tyrosine kinases including RET,
MET and VEGFR2. These receptor tyrosine kinases are involved in both normal
cellular function and in pathologic processes such as oncogenesis, metastasis,
tumor angiogenesis, and maintenance of the tumor microenvironment.
Exelixis received approval by the FDA to market COMETRIQ in the United States
for the treatment of progressive, metastatic MTC in November 2012. Please see
important safety information below, and the full prescribing information,
including Boxed Warning, for COMETRIQ at www.exelixis.com or www.COMETRIQ.com.

COMETRIQ(TM) Important Safety Information, including Boxed Warning

  * WARNING: PERFORATIONS AND FISTULAS, and HEMORRHAGE
    Serious and sometimes fatal gastrointestinal perforations and fistulas occur
    in COMETRIQ-treated patients.
  * Severe and sometimes fatal hemorrhage occurs in COMETRIQ-treated patients.
  * COMETRIQ treatment results in an increase in thrombotic events, such as
    heart attacks.
  * Wound complications have been reported with COMETRIQ.
  * COMETRIQ treatment results in an increase in hypertension.
  * Osteonecrosis of the jaw has been observed in COMETRIQ-treated patients.
  * Palmar-Plantar Erythrodysesthesia (PPE) Syndrome occurs in patients treated
    with COMETRIQ.
  * The kidneys can be adversely affected by COMETRIQ. Proteinuria and nephrotic
    syndrome have been reported in patients receiving COMETRIQ.
  * Reversible Posterior Leukoencephalopathy Syndrome has been observed with
    COMETRIQ.
  * COMETRIQ can cause fetal harm when administered to a pregnant woman.

Adverse Reactions - The most commonly reported adverse drug reactions (equal to
or more than 25%) are diarrhea, stomatitis, palmar-plantar erythrodysesthesia
syndrome (PPES), decreased weight, decreased appetite, nausea, fatigue, oral
pain, hair color changes, dysgeusia, hypertension, abdominal pain, and
constipation. The most common laboratory abnormalities (equal to or more than
25%) are increased AST, increased ALT, lymphopenia, increased alkaline
phosphatase, hypocalcemia, neutropenia, thrombocytopenia, hypophosphatemia, and
hyperbilirubinemia.

Drug Interactions - COMETRIQ is a CYP3A4 substrate. Co-administration of strong
CYP3A4 inhibitors can increase cabozantinib exposure. Chronic co-administration
of strong CYP3A4 inducers can reduce cabozantinib exposure.

For full prescribing information, including Boxed Warning, please visit
www.exelixis.com or www.COMETRIQ.com.

About Exelixis
Exelixis, Inc. is a biotechnology company committed to developing small molecule
therapies for the treatment of cancer. Exelixis is focusing its proprietary
resources and development efforts exclusively on COMETRIQ(TM) (cabozantinib).
Exelixis has also established a portfolio of other novel compounds that it
believes have the potential to address serious unmet medical needs, many of
which are being advanced by partners as part of collaborations. For more
information, please visit the company's web site at www.exelixis.com.


About Sobi Partner Products
Sobi Partner Products (SPP) is a business unit within Sobi which offers a unique
commercial platform for partners with niche and specialty products. SPP provides
extensive knowledge and local experience through our direct presence across EU,
Eastern Europe, Russia, Middle East and North Africa. We apply an integrated
commercial, medical, and market access approach to products which address
important unmet needs, working from named patient use (NPU) programs through to
reimbursement and commercialization, primarily in the Centre of Expertise
setting. The key SPP therapeutic areas are Oncology, Hematology, Infectious
Diseases, and Emergency Medicines & Antidotes.

About Sobi
Sobi is an international specialty healthcare company dedicated to rare
diseases. Our mission is to develop and deliver innovative therapies and
services to improve the lives of patients. The product portfolio is primarily
focused on inflammation and genetic diseases, with three late stage biological
development projects within haemophilia and neonatology. We also market a
portfolio of specialty and rare disease products for partner companies. Sobi is
a pioneer in biotechnology with world-class capabilities in protein biochemistry
and biologics manufacturing. In 2012, Sobi had total revenues of SEK 1.9 billion
(€ 215 M) and about 480 employees. The share (STO: SOBI) is listed on NASDAQ OMX
Stockholm. More information is available at www.sobi.com.

The above information has been made public in accordance with the Swedish
Securities Market Act and/or the Financial Instruments Trading Act. The
information was released for public distribution on 22 February 2013 at 08.30
CET.