Sobi to present new data at the 2023 EHA congress
Sobi® will present data at the EHA (European Haematology Association) hybrid congress taking place in Frankfurt, Germany 8-11 June, 2023, highlighting the company’s commitment in rare haematological diseases. During the congress, Sobi will present important new data on haemophilia, immune thrombocytopenia, relapsed or refractory diffuse large b-cell lymphoma (DLBCL), and paroxysmal nocturnal haemoglobinuria.
“We look forward to discussing new data related to several of Sobi’s therapeutic areas with haematologists at this year’s EHA congress. This marks Sobi’s entry into onco-haematology with a satellite symposium on DLBCL,” said Tony Hoos, MD, PhD, Head of Research & Development and Chief Medical Officer. “Connecting in person and online with physicians at EHA helps us to understand the needs in clinical practice and advance medical progress together.”
Key data to be presented at the EHA congress 2023
| Hemofili | Presentationsform: |
| Assessment of joint health in patients receiving prophylaxis for haemophilia A in five European countries: a cross-sectional surveyDe la Corte‐Rodriguez H, Bystrická L, Ball N, Olsen S, Golden K, Hakimi Z, Kragh N | #S300 Lördag 10 juni, kl. 16:30–16:45 CEST Muntlig presentation |
| A 2022 Cross-National Survey of People Living with Haemophilia during the COVID-19 Pandemic: Views on Vaccination- and Infection-Related Risks in Central EuropeBoban A, Banchev A, Batorova A, Brînză M, Faganel Kotnik B, Pintilie-Ancuta L, Zapotocka E | #P1630Fredag 9 juni, kl. 18:00–19:00 CESTPosterpresentation |
| A Cross-National Survey of People Living with Hemophilia: Reported Pain, Impact on Physical Activity and Opportunity on Using Digital Tools for Monitoring Haemophilia in Central EuropeBanchev A, Batorova A, Boban A, Brînză M, Faganel Kotnik B, Pintilie-Ancuta L, Zapotocka E | #P1620Fredag 9 juni, kl. 18:00–19:00 CEST Posterpresentation |
| Paroxysmal nokturn hemoglobinuri | |
| Sobi | |
| Evaluation Of Pegcetacoplan Treatment Success In Paroxysmal Nocturnal Hemoglobinuria With and Without Bone Marrow Failure: A Move Towards Individualized Patient TreatmentSzer J, Panse J, Kulasekararaj A, Oliver M, Fattizzo B, Nishimura J, Szamosi J, Horneff R, Peffault de Latour R | #P781Fredag 9 juni, kl. 18:00–19:00 CEST Posterpresentation |
| Evaluation Of Pegcetacoplan In Paroxysmal Nocturnal Hemoglobinuria Patients With Aplastic Anemia In The Prince StudyBogdanovic A, Tse E, Yeh M, Szamosi J, Wong R | # P794Fredag 9 juni, kl. 18:00–19:00 CESTPosterpresentation |
| Samarbete Sobi/Apellis | |
| Thrombosis and Meningococcal Infection Rates in Pegcetacoplan Patients with Paroxysmal Nocturnal Hemoglobinuria in the Clinical Trial and Post-Marketing Settings Kelly R, Nishimori H, Horneff R, Hillmen P, Savage J, Al-Adhami M, Lallier S, Gerber G | #P786 Fredag 9 juni, kl. 18:00–19:00 CEST Posterpresentation |
| Diffust storcelligt B-cellslymfom | |
| Long-term responses with loncastuximab tesirine: updated results from lotis-2, the pivotal phase 2 study in patients with relapsed/refractory diffuse large b-cell lymphoma Caimi PF, Ai WZ, Alderuccio JP, Kirit MA, Hamadani M, Hess B, Kahl BS, Radford J, Solh M, Stathis A, Zinzani PG, Wang Y, Qin Y, Wang L, Xu C, Carlo.Stella C | #P1132 Fredag 9 juni, kl. 18:00–19:00 CEST Posterpresentation |
| Immunologisk trombocytopeni | |
| Fosun China Phase 3 Efficacy and safety of avatrombopag for the treatment of chronic immune thrombocytopenia in a Chinese adult population: A multicenter, randomized phase III trialHeng Mei, Hu Zhou, Ming Hou, Jing Sun, Lei Zhang, Jianmin Luo, Zhongxing Jiang, Xu Ye, Yajing Xu, Jun Lu, Hui Wang, Aimin Hui, Yongchun Zhou, Yu Hu. | #P1611Fredag 9 juni, kl. 18:00–19:00 CEST Posterpresentation |
About Alprolix®
Alprolix® (eftrenonacog alfa) is a recombinant clotting factor therapy developed for haemophilia B using Fc fusion technology to prolong circulation in the body. It is engineered by fusing factor IX to the Fc portion of immunoglobulin G subclass 1, or IgG1 (a protein commonly found in the body), enabling Alprolix to use a naturally occurring pathway to extend the time the therapy remains in the body (half-life). Alprolix is manufactured using a human cell line in an environment free of animal and human additives. Alprolix is approved and marketed by Sobi for the treatment of haemophilia B in the EU, the UK, Iceland, Kuwait, Liechtenstein, Norway, Saudi Arabia and Switzerland. It is also approved in the United States, Canada, Japan, Australia, New Zealand and other countries where Sanofi has the marketing rights.
About Elocta®/Eloctate®
Elocta®/Eloctate® (efmoroctocog alfa) is a recombinant clotting factor therapy developed for haemophilia A using Fc fusion technology to prolong circulation in the body. It is engineered by fusing factor VIII to the Fc portion of immunoglobulin G subclass 1, or IgG1 (a protein commonly found in the body), enabling Elocta to use a naturally occurring pathway to extend the time the therapy remains in the body (half-life). Elocta is manufactured using a human cell line in an environment free of animal and human additives. Elocta is approved and marketed by Sobi for the treatment of haemophilia A in the EU, the UK, Iceland, Kuwait, Liechtenstein, Norway, Saudi Arabia and Switzerland. It is approved and marketed as Eloctate® (Antihemophilic Factor [Recombinant], Fc Fusion Protein) by Sanofi in the United States, Canada Japan, Australia, New Zealand and other countries, where Sanofi has the marketing rights.
About the Sanofi and Sobi collaboration
Sobi and Sanofi collaborate on the development and commercialization of Alprolix® and Elocta®/Eloctate®. The companies also collaborate on the development and commercialisation of efanesoctocog alfa or ALTUVIIIO in the US. Sobi has final development and commercialisation rights in the Sobi territory (essentially Europe, North Africa, Russia, and most Middle Eastern markets). Sanofi has final development and commercialisation rights in North America and all other regions in the world excluding the Sobi territory.
About Aspaveli®/ Empaveli®
Aspaveli/Empaveli (pegcetacoplan) is a targeted C3 therapy designed to regulate excessive activation of the complement cascade, a part of the body’s immune system, which can lead to the onset and progression of many serious diseases. Aspaveli/Empaveli is approved for the treatment of paroxysmal nocturnal haemoglobinuria (PNH) in the European Union and the United Kingdom as Aspaveli and in the United States, Canada, Australia, and Saudi Arabia as Empaveli. Aspaveli/Empaveli is also under investigation for several other rare diseases across haematology and nephrology.
About the Sobi and Apellis collaboration
Sobi and Apellis have global co-development rights for systemic pegcetacoplan. Sobi has exclusive ex-US commercialisation rights for systemic pegcetacoplan, and Apellis has exclusive US commercialisation rights for systemic pegcetacoplan and retains worldwide commercial rights for ophthalmological pegcetacoplan, including for geographic atrophy (GA).
About Zynlonta®
Zynlonta (loncastuximab tesirine) is a CD19-directed antibody drug conjugate. Once bound to a CD19-expressing cell, Zynlonta is internalised by the cell, where enzymes release a pyrrolobenzodiazepine payload. The potent payload binds to DNA minor groove with little distortion, remaining less visible to DNA repair mechanisms. This ultimately results in cell cycle arrest and tumour cell death. Zynlonta® is a registered trademark of ADC Therapeutics SA.
About ADC Therapeutics
ADC Therapeutics (NYSE: ADCT) is a commercial-stage biotechnology company improving the lives of those affected by cancer with its next-generation, targeted antibody drug conjugates (ADCs). The Company is advancing its proprietary PBD-based ADC technology to transform the treatment paradigm for patients with hematologic malignancies and solid tumours.
ADC Therapeutics is based in Lausanne (Biopôle), Switzerland and has operations in London, the San Francisco Bay Area and New Jersey. For more information, please visit https://adctherapeutics.com/ and follow the Company on Twitter and LinkedIn.
About Doptelet®
Doptelet (avatrombopag) is an orally administered thrombopoietin receptor agonist (TPO-RA) that mimics the biologic effects of TPO in stimulating the development and maturation of megakaryocytes, resulting in increased platelet count. It is approved in the European Union, the United States and several other countries for the treatment of thrombocytopenia in adult patients with chronic liver disease who are scheduled to undergo an invasive procedure, and for the treatment of thrombocytopenia in adult patients with chronic immune thrombocytopenia (ITP) who have had an insufficient response to a previous treatment. Chronic ITP is a rare autoimmune bleeding disorder characterised by low number of platelets and increased bleeding risk. The incidence of primary ITP in adults is 3.3/100,000 adults per year with a prevalence of 9.5 per 100,000 adults (Lambert et al. Blood 2017).
Sobi
Sobi® is a specialised international biopharmaceutical company transforming the lives of people with rare and debilitating diseases. Providing reliable access to innovative medicines in the areas of haematology, immunology and specialty care, Sobi has approximately 1,600 employees across Europe, North America, the Middle East, Asia and Australia. In 2022, revenue amounted to SEK 18.8 billion. Sobi’s share (STO:SOBI) is listed on Nasdaq Stockholm. More about Sobi at sobi.com, LinkedIn and YouTube.
Contacts
For details on how to contact the Sobi Investor Relations Team, please click here. For Sobi Media contacts, click here.
Swedish Orphan Biovitrum AB (publ)
Postal address SE-112 76 Stockholm, Sweden
Phone: 46 8 697 20 00 www.sobi.com