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UTA biochemists are advancing research into autism, Alzheimer’s disease and Down syndrome

Biochemists at The University of Texas at Arlington are mapping the catalytic processes of sulfur-oxidizing enzymes to improve understanding of the chemical imbalances found in patients with autism, Alzheimer’s disease and Down syndrome. “Little is known about how sulfur-oxidizing enzymes work, or how or why autistic, Alzheimer and Down syndrome patients demonstrate abnormal sulfur metabolism,” said Brad Pierce, UTA assistant professor of biochemistry and principal investigator on the project. “Our work is to retro-engineer the sulfur oxidation process and map out the chemical

Research uses data mining to help early identification, prevention of Alzheimer’s disease

Harnessing big dataA University of Texas at Arlington computer scientist will analyze complex data and use imaging genomics to predict a person’s probability of contracting Alzheimer’s disease. Heng Huang, a professor in the Computer Science and Engineering Department , won a five-year, $2 million grant through the National Institutes of Health to use multi-dimensional and longitudinal imaging genomic data to identify biomarkers that may be used for early prediction of Alzheimer’s disease, with the hope that the effects of the disease may be reversed or prevented.

UT Arlington professor to use National Science Foundation grant to examine vital enzymes, mentor young scientists

The National Science Foundation has awarded a three-year, $300,000 grant to a UT Arlington biochemist working to unravel the mystery of how enzymes regulate the human body. Brad Pierce, an assistant professor in the Department of Chemistry and Biochemistry, is studying a new class of enzymes that are catalysts for the oxidation, or breaking down, of sulfur-bearing molecules in the body. Enzymes involved in sulfur-oxidation are increasingly being recognized as potential drug targets for development of antimicrobials and therapies for cancer and inflammatory diseases such as arthritis. "

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