New publication - Attana’s technology was used to develop an antibody for matching donor and patient for transplantations
In a new paper published in Nature Communications by the group of Prof. MacAry at National University of Singapore, they present the development and characterization of an antibody targeting a cell surface receptor, which is involved in regulation of the immune system. TThe aim is to avoid an unwanted immune response at transplantations.
At e.g. blood transfusion, transplantation or pregnancy it is common with an unwanted immune response. Prof. MacArys team describes in the paper how they have developed a so called alloantibody. Alloantibodies are antibodies in an individual that react with antigens produced by members of the same species. Alloantibody responses against certain cell surface receptors that are involved in the regulation of the immune system, so-called HLA molecules, can be triggered by events such as blood transfusion, transplantation or pregnancy. For example, if an alloantibody interacts to an HLA molecule on grafted tissues it can result in the activation of players of the immune system to attack the graft. In this article, a recombinant monoclonal antibody against a common Asian HLA allele, HLA-A*11:01, was isolated using phage display. Thereafter, a thorough biochemical/biophysical and functional characterization of the antibody was performed. It has been proposed that affinity is a critical factor affecting the pathogenicity of alloantibodies. Thus, Attana’s technology was used to determine the affinity and analyze the kinetic interaction profile of the antibody.
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