Study Shows Significant Improvement in Mood, Cortisol Levels with Proprietary Blend of Magnolia officinalis and Phellodendron amurense (Relora(R))

Salinas, California - May 2, 2013 - Dr. Shawn Talbott presented a new study on Reloraâ  at the Experimental Biology 2013 Meeting. The study, conducted by Supplement Watch/GLH Nutrition, found that a proprietary blend of Magnolia officinalis and Phellodendron amurense significantly improved mood and other psychological states in moderately stressed subjects.

The study randomly assigned 60 subjects (56 of whom successfully completed the study) experiencing moderate levels of perceived psychological stress to take Relora or a placebo twice a day for four weeks, a time period selected to minimize the influence of short-term mood changes that result from daily stressors.  All subjects submitted three saliva samples (morning, mid-day and evening) for cortisol testing and completed a baseline Profile of Mood States questionnaire (POMS) on the first and last day of the study.

The results indicated that daily use of Relora reduced cortisol exposure and perceived stress while improving a variety of mood parameters – most significantly, anger (reduced by 42%) and fatigue (reduced by 31%).

“These are exciting results that suggest Relora may be an effective natural approach to managing the detrimental effects of chronic stress without the tranquilizing side effects of pharmaceutical agents”, said Research Director, Shawn Talbott, PhD.

Other indicators measured in the study include overall stress (reduced by 11%), tension (reduced by 13%), depression (reduced by 20%) and confusion (reduced by 27%). Salivary cortisol exposure decreased by 18%.  No adverse side effects were reported.

Relora (US Patent No. 6,582,735) is a blend of Magnolia officinalis and Phellodendron amurense. These botanicals have been used in Traditional Chinese Medicine for thousands of years. In the West, they have been recognized for treating stress. When compared to prescription drugs, Honokiol and Berberine, two of the active constituents in Relora, appear effective at calming stress without sedative side effects.

Experimental Biology 2013 is a multidisciplinary, scientific annual meeting of approximately 14,000 scientists and exhibitors along with six sponsoring societies and 30 guest societies. General fields of study that attend Experimental Biology include anatomy, physiology, pathology, biochemistry, nutrition, and pharmacology. 

Relora is a product of Next Pharmaceuticals and is widely used as an ingredient in stress and weight management categories throughout the dietary supplement industry.

For more information on this and other studies conducted on Relora, visit

Ashley Beleny

Environmental Relations PR

(831) 649-2334

Founded in 1997, Next Pharmaceuticals provides patented, science-based natural ingredients for healthy living products in the dietary supplement, food and beverage industries. Next has successfully developed six patented and proprietary plant extracts in addition to Chromulin®, a new, safer form of the essential trace mineral chromium. Next products help consumers cope with many of today’s most prevalent and chronic health issues, significantly expanding the choices for self-care products while providing consumer brands with powerful product differentiation. Next proprietary formulations include Relora® for stress, stress-related eating and weight management; Seditol® for improved, more restful sleep; Citri-Z® for heart health; Flavoxine® for balanced cholesterol levels; Nexrutine® for the aches and pains associated with physical activity, exercise and over-exertion; Citrofen® for joint mobility and comfort; and Chromulin® for optimum metabolism.  For more information, visit