Scientists Discover Potential Avenue to Treating Type 2 Diabetes at Early Stages
Gene-regulating protein controls fat storage and insulin sensitivity in muscleResearchers at Sanford Burnham Prebys Medical Discovery Institute (SBP) have identified a new potential target for drugs to prevent type 2 diabetes. A paper published today in the Journal of Clinical Investigation shows that blocking a cellular glucose sensor in muscle improves insulin responsiveness.
“Our new study shows that a protein called MondoA may serve as a key link between insulin resistance and accumulation of fat in muscle, which occurs in obesity-related diabetes,” said Daniel P. Kelly, M.D.,
Discovery provides proof of principle for safe, targeted delivery of drugs to the placenta to improve pregnancy outcomesNearly 10 percent of babies born in the United States are born premature, according to the March of Dimes. The underlying cause of many complications during pregnancy is often a poorly functioning placenta, the organ that nourishes and maintains the fetus.
A new study by an international team of researchers, including Erkki Ruoslahti, Ph.D. , distinguished professor at Sanford Burnham Prebys Medical Discovery
