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  • University of Eastern Finland
    Joensuu / Kuopio
    http://www.uef.fi/en
  • Joensuu Campus
    Yliopistokatu 2 P.O. Box 111 FI-80101 Joensuu
  • Kuopio Campus
    Yliopistonranta 1 P.O. Box 1627 FI-70211 Kuopio
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    Obesity-fighting drugs may reduce alcohol consumption in individuals with alcohol use disorder

    A new joint study by the University of Eastern Finland and Karolinska Institutet in Sweden found that the GLP-1 agonists semaglutide and liraglutide, which are used for treating diabetes and obesity, were associated with fewer hospitalisations among individuals with alcohol use disorder, AUD. Fewer hospitalisations were observed for alcohol related causes, substance use related causes, and for physical illnesses. However, no association was observed for hospitalisations due to attempted suicide. Effective treatments for alcohol dependence exist; however, they remain underused and are not

    Metabolomic changes linked to psychotic-like experiences and cannabis use in adolescents

    An exploratory study conducted at the University of Eastern Finland has examined metabolomic patterns associated with psychotic-like experiences in adolescents, highlighting the influence of cannabis use. These findings suggest that specific metabolite patterns associated with psychotic-like experiences may vary between cannabis users and non-users, potentially reflecting different underlying molecular pathways in psychotic-like experiences. The study analysed blood samples from 76 adolescent outpatients experiencing depression, using mass spectrometry to assess metabolite concentrations.

    Finland introduces a new care pathway for epilepsy

    The Finnish epilepsy care pathway has been published in Epilepsia Open. This Finnish model for epilepsy care provides a streamlined, multidisciplinary approach to the diagnosis and treatment of epilepsy, and combines modern digital tools, data sharing and peer support. The Finnish epilepsy care pathway can serve to model how integrated healthcare systems can effectively manage complex conditions. “The Finnish model could serve as a template for other healthcare systems looking for a benchmark to improve their epilepsy care,” says Professor Reetta Kälviäinen of the University of Eastern

    Students’ challenges in general upper secondary education should be better acknowledged – school burnout can be prevented with the right measures

    School burnout can manifest in students in different ways. Some might feel tired or anxious, while in others, burnout may manifest as a negative attitude towards school. Early detection of the various signs and symptoms of burnout is important, as it is likely that a student experiencing burnout symptoms in one area will later experience them in other areas, too. Conducted at the University of Eastern Finland, a recent study following more than 200 Finnish general upper secondary school students over three years explored associations of students’ perceived and received support, student

    Health, financial and social support resources can help to maintain subjective well-being from the age of fifty until very old age

    A new study conducted by researchers at the University of Eastern Finland sheds light on how people’s health, financial situation and social resources contribute to their subjective well-being, and whether this differs at the age of 50 or at older ages. The results show that life satisfaction remains high until very old age, but eudaemonic quality of life starts to decline already after the age of 70. The study analysed data from 75,895 citizens aged 50 to 105, across 27 European countries. The researchers employed two distinct measures of subjective well-being: evaluative life

    Workplace culture and social relationships are associated with workplace bullying

    Workplace bullying poses a serious threat to employees’ health and well-being. Conducted at the University of Eastern Finland, a recent study sheds new light on the impact of social relationships on workplace bullying. Focusing on the dynamics of social relationships, the study shows how workplace culture, interaction and social relationships play a role in bullying. Workplace bullying is a complex phenomenon where the bully can be a colleague, a supervisor, a workplace clique or even the entire work community. “Our research draws attention to the fact that workplace bullying is not

    Depression challenges the work and functional capacity of young adults in Finland both at work and in leisure time

    Depression and other mental health issues reduce the number of productivity-adjusted life years (PALYs) more than musculoskeletal diseases or cardiovascular diseases, according to a recent joint study by the University of Eastern Finland, the Finnish Social Insurance Institution (Kela), and Monash University in Australia. The study was the first to examine the loss of PALYs due to chronic conditions at the population level in Finland. The results were published in Value in Health, a highly regarded journal in health economics.PALY is a new metric developed at Monash University that allows

    Analysis of retinal proteins identifies new drug targets for treating inherited retinal degenerations

    An international team of researchers has identified new drug targets for therapies that could benefit patients with different forms of retinitis pigmentosa and other inherited retinal diseases. Using advanced proteomics techniques, they unveiled shared critical pathways in retinitis pigmentosa disease models. The study represents significant progress in understanding how the proteome may change in different retinal dystrophies. Published in Molecular & Cellular Proteomics, the study was carried out by researchers from the University of Eastern Finland (UEF), the University of California,

    Employees should not bear the sole responsibility for learning in remote work

    Competence requirements in the workplace are growing at a tremendous pace as technology advances and remote work is becoming increasingly normalised. Work-related formal training, too, increasingly takes place on online platforms. However, online courses completed alongside other work tasks are by no means unproblematic, nor is informal learning online. Inadequate pedagogical implementation of online training, combined with unrealistic expectations of participation and efficiency, can lead to certificates of completion rather than professional development, while other informal learning

    Maternal exercise during pregnancy may protect the child against asthma

    The risk of asthma in the child can be reduced by nearly half if the mother engages in active physical exercise at least three times a week during pregnancy, compared to a child of a mother who is less active, a new study by the University of Eastern Finland (UEF), Kuopio University Hospital (KUH) and the Finnish Institute for Health and Welfare (THL) shows. The researchers utilised data from nearly 1,000 mother-child pairs in the Kuopio Birth Cohort study, KuBiCo, followed from pregnancy until the child was seven years old. Maternal exercise during pregnancy is known to have positive

    Transition to low-carbon futures: new research uncovers rise in legal challenges to climate action

    As the global push towards low-carbon societies accelerates, a new study reveals that justice concerns are increasingly surfacing in legal disputes over climate policies and projects. This phenomenon, described as “just transition litigation”, emphasises the need to balance climate action with social justice considerations, ensuring that vulnerable communities are not disproportionately impacted. A growing legal phenomenon As the world races to reduce greenhouse gas emissions and adapt to the impacts of climate change, the transition to low-carbon societies has sparked new questions

    Fear of childbirth is associated with shorter duration of breastfeeding

    The duration of breastfeeding is shorter than average among mothers with a fear of childbirth – regardless of the mode of delivery, a new study from Finland shows. According to the researchers, the fear of childbirth can also be an indication of a greater need for breastfeeding support. Using data from the Kuopio Birth Cohort study, KuBiCo, the study examined factors related to childbirth that may affect the success and duration of breastfeeding in the child’s first year of life. The researchers analysed data collected in 2013–2020, which included 2,521 women who had given birth in

    Inflammatory cells in tumour microenvironment promote the transformation of prostate cancer cells into treatment-resistant cells

    There is a challenge related to prostate and many other cancers that cancer cells form resistance to treatments as the disease progresses. However, these resistance mechanisms are not yet fully understood. A new study by the University of Eastern Finland found that inflammation-promoting immune cells, M1 macrophages, can transform cancer cells into stem-like cells and thus immune to treatment. The results were published in OncoImmunology journal. The study examined the impact of factors promoting inflammation in a tumour microenvironment on the progression of prostate cancer. Researchers

    Plant-derived secondary organic aerosols can act as mediators of plant-plant interactions

    A new study published in Science reveals that plant-derived secondary organic aerosols (SOAs) can act as mediators of plant-plant interactions. This research was conducted through the cooperation of chemical ecologists, plant ecophysiologists and atmospheric physicists at the University of Eastern Finland. It is well known that plants release volatile organic compounds (VOCs) into the atmosphere when damaged by herbivores. These VOCs play a crucial role in plant-plant interactions, whereby undamaged plants may detect warning signals from their damaged neighbours and prepare their

    Lifestyle intervention from childhood to adolescence affects metabolism even years later

    A new study from the University of Eastern Finland (UEF) uncovers how early lifestyle changes can have long-lasting impacts. A diet and physical activity intervention in childhood and adolescence was found to profoundly influence metabolism even years later. The Physical Activity and Nutrition in Children (PANIC) study is the first lifestyle intervention study using advanced liquid chromatography-mass spectrometry (LC-MS) metabolomics technology to analyse molecular mechanisms underlying the health effects of lifestyle changes from childhood to adolescence. By analysing blood samples,

    Lack of workplace support after medication errors can worsen outcomes among healthcare professionals

    Psychological distress is the most common negative outcome experienced by healthcare professionals after making medication errors, according to a new study from the University of Eastern Finland. After such events, turnover intentions and absenteeism were more common among those experiencing inadequate organisational support and so called second victim distress. During this past decade, an abundance of research has been conducted regarding the prevalence and severity of the second victim phenomenon. The term “second victim”, coined by Dr. Albert Wu from Johns Hopkins University, refers

    Novel AI algorithm assists in breast cancer screening

    Researchers at the University of Eastern Finland have developed a novel artificial intelligence based algorithm, MV-DEFEAT, to improve mammogram density assessment. This development holds promise for transforming radiological practices by enabling more precise diagnoses. High breast tissue density is associated with an increased risk of breast cancer, and breast tissue density can be estimated from mammograms. The accurate assessment of mammograms is crucial for effective breast cancer screening, yet challenges such as variability in radiological evaluations and a global shortage of

    Obesity-induced inflammation increases the secretion of extracellular vesicles from adipose tissue

    New research from the University of Eastern Finland sheds light on the mechanisms associating obesity with inflammation by exploring tiny membrane particles, known as extracellular vesicles, secreted by human adipocytes. The study found that obesity-induced adipose tissue inflammation increased the secretion of extracellular vesicles, which may contribute to the detrimental health effects of obesity. The findings were published in Journal of Translational Medicine.When people gain weight, their adipose tissue expands, which gradually leads to its inflammation, and to insulin resistance.

    Pioneering study identifies six genetic regions associated with normal pressure hydrocephalus

    A new study by the University of Eastern Finland and partners identified new genetic variants associated with normal pressure hydrocephalus (NPH). Published in Neurology, the study is the first large-scale genome-wide association study related to NPH in the world. The results provide new insights into the genetic background of NPH and provide a basis for further research into the specific biological mechanisms underlying the condition.NPH is a chronic neurological syndrome in the elderly that affects gait, memory and bladder control. The current treatment for NPH is shunt surgery. The

    Season of birth is associated with the development of asthma and allergic rhinitis

    Being born in autumn or winter is associated with asthma and allergic rhinitis in Finland, a new registry-based study shows.Season of birth, and specifically being born in autumn or winter, is associated with allergic rhinitis and asthma in Finland, a new study by the University of Eastern Finland, the University of Helsinki and Helsinki University Hospital shows. Conversely, being born in summer was associated with the lowest incidence of asthma and allergic rhinitis. “When using summer as a reference, we found that being born in any other time of the year was significantly associated

    Type 2 diabetes can be prevented by diet and exercise even in individuals with a high genetic risk

    A new study from the University of Eastern Finland is the first in the world to show that a healthy diet and regular exercise reduce the risk of type 2 diabetes even in individuals with a high genetic risk. In other words, everyone benefits from lifestyle changes, regardless of genetic risk. Type 2 diabetes is a global problem. According to the International Diabetes Federation, IDF, one in eleven adults worldwide has diabetes, with type 2 diabetes accounting for 90 per cent of the cases. To date, researchers have identified more than 500 genetic variants that predispose individuals to

    Early onset dementia more common than previously reported – the incidence of Alzheimer’s disease seems to be on the rise

    A new major study by the University of Eastern Finland, the University of Oulu and Neurocenter Finland explored early-onset dementia in the working-age population in Finland. The study cohort was one of the largest in the world to date, and the findings were published on 24[th] of July 2024 in Neurology®, the medical journal of the American Academy of Neurology.Current epidemiological data on early-onset dementia is scarce and based on small study cohorts, with no recent data from Finland available. For the present study, researchers analysed patient data registries of Kuopio and Oulu

    Traffic-related ultrafine particles hinder mitochondrial functions in olfactory mucosa

    Ultrafine particles, UFPs, the smallest contributors to air pollution, hinder the function of mitochondria in human olfactory mucosa cells, a new study shows. Led by the University of Eastern Finland, the study showed that traffic-related UFPs impair mitochondrial functions in primary human olfactory mucosa cells by hampering oxidative phosphorylation and redox balance. Furthermore, the responses of olfactory mucosa cells of individuals with Alzheimer’s disease differed from those of cognitively healthy controls. The findings were published in Redox Biology. Air pollution forms a major

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