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  • University of Eastern Finland
    Joensuu / Kuopio
    http://www.uef.fi/en
  • Joensuu Campus
    Yliopistokatu 2 P.O. Box 111 FI-80101 Joensuu
  • Kuopio Campus
    Yliopistonranta 1 P.O. Box 1627 FI-70211 Kuopio
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    Psychotropic polypharmacy is common in Alzheimer’s disease

    Up to half of people with Alzheimer’s disease (AD) use a psychotropic drug, and one in five uses two or more psychotropics concomitantly, according to a study conducted at the University of Eastern Finland. Psychotropic drug use was more common among persons with Alzheimer’s disease already five years before the diagnosis, and the difference to comparison persons without AD increased at the time of diagnosis. Four years after the diagnosis, psychotropic drug use was three times more common in persons with AD than in comparison persons. Of psychotropic drugs, the use of antipsychotics

    Opioid analgesics reduce use of antipsychotics in persons with Alzheimer’s disease

    Initiating an opioid analgesic reduced the use of antipsychotics and benzodiazepines in persons with Alzheimer’s disease, a recent study from the University of Eastern Finland shows. These drugs are frequently prescribed to treat behavioural and psychiatric symptoms of dementia, which can be worsened by other symptoms, such as pain. The results were published in International Psychogeriatrics. The researchers analysed the use of antipsychotics and benzodiazepines six months before and six months after persons with Alzheimer’s disease begun using an opioid. These results were then

    Antipsychotic drug use increases risk of mortality among persons with Alzheimer’s disease

    Antipsychotic drug use is associated with a 60 percent increased risk of mortality among persons with Alzheimer's disease, shows a recent study from the University of Eastern Finland. The risk was highest at the beginning of drug use and remained increased in long-term use. Use of two or more antipsychotic drugs concomitantly was associated with almost two times higher risk of mortality than monotherapy. The results were published in the Journal of Alzheimer’s Disease. The study compared the risk of mortality between the most commonly used antipsychotic drugs. Haloperidol was associated

    More than half of persons with Alzheimer’s disease aged 90 years or more use psychotropic drugs

    Psychotropic drug use is rather common among persons aged 90 years of more diagnosed with Alzheimer’s disease compared with those who were diagnosed at younger age, concludes study conducted at University of Eastern Finland. Persons aged 90 years or more used antipsychotics 5 times and antidepressants 2.5 times more often than those without the disease in the same age group. The results were published in Age and Ageing journal. 56% of persons aged 90 years or more with Alzheimer’s disease use psychotropic drugs whereas the same figure was 48% among younger persons with Alzheimer’s

    Antipsychotic medications linked to increased risk of pneumonia in persons with Alzheimer’s disease

    Antipsychotic medications are associated with an increased risk of pneumonia in persons with Alzheimer’s disease (AD), according to new research from the University of Eastern Finland. The risk of pneumonia was the highest at the beginning of antipsychotic treatment, remaining elevated also in long-term use. No major differences were observed between the most commonly used antipsychotics. Pneumonia was listed as one of the leading causes of death in the FDA’s 2005 warning on the use of antipsychotics for the treatment of behavioural and psychological symptoms of dementia. Since then,

    Antipsychotics initiated frequently and used for long term in Alzheimer's patients

    Antipsychotic drugs are initiated in patients with Alzheimer's disease (AD) more frequently than in the general population – already 2–3 years before the Alzheimer's diagnosis, according to a new study from the University of Eastern Finland. Most commonly, antipsychotics were initiated during the six months following the Alzheimer's diagnosis; however, the incidence of new antipsychotic users was high also later on. The results were published in British Journal of Psychiatry. The study analysed the incidence of antipsychotic use eight years before and four years after the Alzheimer's

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