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  • University of Eastern Finland
    Joensuu / Kuopio
    http://www.uef.fi/en
  • Joensuu Campus
    Yliopistokatu 2 P.O. Box 111 FI-80101 Joensuu
  • Kuopio Campus
    Yliopistonranta 1 P.O. Box 1627 FI-70211 Kuopio
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    Depression linked to reduced arginine levels

    People suffering from major depressive disorder, MDD, have reduced arginine levels, a new study from the University of Eastern Finland shows. Arginine is an amino acid which the body uses to produce, e.g., nitric oxide. Nitric oxide, in turn, is a nervous system and immune defence mediator, and it also plays a role in vascular regulation. The global arginine bioavailability ratio, GABR, is an indicator of the body’s arginine levels, and the ratio has previously been used to measure the body’s capacity to produce nitric oxide. Reduced arginine bioavailability is also known to be an

    Antidepressant use increases risk of head injuries among persons with Alzheimer’s disease

    Antidepressant use is associated with an increased risk of head injuries and traumatic brain injuries among persons with Alzheimer’s disease, according to a new study from the University of Eastern Finland. Antidepressant use has previously been linked with an increased risk of falls and hip fractures, but the risk of head injuries has not been studied before. The results were published in Alzheimer’s Research & Therapy. Antidepressant use was associated with a higher risk of head injuries especially at the beginning of use – during the first 30 days –, but the risk persisted even longer,

    Depression, adverse childhood events and sleep disturbances linked to changes in the immune system

    Adverse childhood experiences and sleep disturbances interfere with immune system regulation, shows research from the University of Eastern Finland. These changes were observed in a population that already carried a significant burden of psychological symptoms such as depression. Major depressive disorder (MDD), adverse childhood experiences and sleep disturbances are all characterised by increased physical morbidity and changes in the way our immune system works. However, the interrelationships between the related disease mechanisms are not fully understood yet. The study analysed

    Even mild depressive symptoms result in poorer lumbar spinal stenosis surgery outcome

    Even mild depressive symptoms can weaken the outcome of lumbar spinal stenosis surgery, according to a recent study completed at the University of Eastern Finland and Kuopio University Hospital. Patients with depressive symptoms had a weaker functional capacity post-surgery even five years after surgery. The results were published in The Spine Journal. "The results indicate that attention should be paid to even mild depressive symptoms both before and after the surgery. This would allow health care professionals to recognise patients who might benefit from enhanced psychosocial support

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