US/UK/Canada

Share

Contacts

  • University of Eastern Finland
    Joensuu / Kuopio
    http://www.uef.fi/en
  • Joensuu Campus
    Yliopistokatu 2 P.O. Box 111 FI-80101 Joensuu
  • Kuopio Campus
    Yliopistonranta 1 P.O. Box 1627 FI-70211 Kuopio
    • Pick a time period -
    Tags ( Active)

    Variation in cancer-causing KRAS mutations greater than thought

    The effects of KRAS mutations underlying many different types of cancer are more diverse than previously thought, according to a new study led by the University of Eastern Finland. Different mutations in the same amino acid of the KRAS protein have so varied effects on protein function that they may require different approaches when it comes to treatment and drug development. The findings were published in PLOS Computational Biology. Mutations occurring in the proteins of the human body often constitute a critical factor that predisposes to cancer development. In this sense, one of

    New health benefits discovered in berry pigment

    Naturally occurring pigments in berries, also known as anthocyanins, increase the function of the sirtuin 6 enzyme in cancer cells, a new study from the University of Eastern Finland shows. The regulation of this enzyme could open up new avenues for cancer treatment. The findings were published in Scientific Reports.  Sirtuins are enzymes regulating the expression of genes that control the function of cells through key cellular signalling pathways. Ageing causes changes in sirtuin function, and these changes contribute to the development of various diseases. Sirtuin 6, or SIRT6 for short,

    Disturbances in blood cell gene transcription may lead to leukemia

    Researchers have succeeded in shedding light on the pathogenesis of DNA breakpoints that are associated with leukemia. A mechanism discovered in a recent study can explain up to 90% of DNA damages present in the most common type of leukemia in children. The study was carried out by the University of Eastern Finland and the University of Tampere, and the findings were published in eLife. Leukemia is the most common form of cancer in children. Thanks to several genome-wide studies carried out over the past years, our understanding of the biology of leukemia has increased rapidly. The fact

    Low breast density worsens prognosis in breast cancer

    Even though dense breast tissue is a risk factor for breast cancer, very low mammographic breast density is associated with a worse prognosis in breast cancer patients. Patient survival is affected only when low breast density is combined with an abundance of hyaluronan in the tumour, shows recent research from the University of Eastern Finland and Kuopio University Hospital. The study also found that the existing Nottingham Prognostic Index for breast cancer can be improved by including low mammographic breast density and HER2 status in the index. Breast cancer is the most common

    Targeted treatment for liver cancer under way

    Researchers at the University of Eastern Finland and Eberhard Karls Universität Tübingen have discovered a new molecular mechanism that can be used to inhibit the growth of hepatocellular carcinoma, which is the most common liver cancer. The findings were published in Nature Medicine. The study found that mouse and human liver cancer in which the function of the protein p53 is disturbed or inhibited is dependent on the interaction between the Aurora kinase A (AURKA) and MYC proteins. Interfering the AURKA protein with a specific drug molecule inhibits this interaction and causes cancer

    Low breast density in mammography worsens breast cancer prognosis

    Very low mammographic breast density worsens the prognosis of breast cancer, according to a recent study from the University of Eastern Finland. Disease free survivals as well as overall life expectancies were significantly shorter in women with very low-density breasts in comparison to women with high density breast tissue. The lower the breast tissue density, the less fibroglandular tissue there is compared to fat tissue. In the future, these findings may prove significant for the assessment of breast cancer prognosis and treatment planning. The study involved 270 breast cancer

    Expression of SIP1 protein indicates poor prognosis in pharyngeal cancer

    The expression of SIP1 protein in pharyngeal squamous cell carcinoma tumours often indicates an advanced tumour stage, a high risk of recurrence and a poor prognosis, according to research from the University of Eastern Finland. Based on the results, SIP1 is a potential new prognostic factor for clinical use, helping to single out patients with more aggressive tumour behaviour requiring more intensive therapy and closer follow-up. Ms Anna Jouppila-Mättö, MD, presented the results in her doctoral thesis. Although pharyngeal squamous cell carcinoma (PSCC) is a rather rare disease, its

    There are no items matching the current filter
    There are no more items matching the current filter
    Back to top

    Subscribe

    Twitter