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Earlier unknown molecular-level mechanism may contribute to the growth rate of breast cancer

Researchers at VTT Technical Research Centre of Finland, the University of Turku and the University of Oslo have discovered a previously unknown molecular-level mechanism that may partly explain the increased growth of cancer cells. The study, published in the British Journal of Cancer, showed that high levels of miRNA-378a-5p molecule cause cell division anomalies. This renders the number of chromosomes in cancer cells abnormal, which is known to promote growth and the spread of cancer. In addition, the researchers discovered that elevated miRNA378a-5p levels in breast cancer patients

SmartCell project: Novel plant biotechnology approach for sustainable production of pharmaceutical compounds

European scientists have made ground-breaking discoveries for improving the efficiency of the production of pharmaceuticals through plant biotechnology. Biotechnological production offers a cost-effective and environmentally friendly alternative to the chemical synthesis of rare and complex pharmaceutical compounds currently isolated from plants. The results have been achieved in the European SmartCell project coordinated by VTT Technical Research Centre of Finland. Several expensive anticancer alkaloid blockbusters used in chemotherapy, such as terpenoid indole alkaloids - vinblastine

Novel cancer cell DNA damage repair mechanism unveils

Research with a Finnish background facilitates the development of more effective cancer medicationCancer cells have an exceptional ability to repair damage to their DNA caused during uncontrolled cell division. Scientists have now unveiled a novel piece of the puzzle of cancer cell DNA repair mechanisms that explain the mechanistic changes in the genetic code of cancer cells. These findings result from application of the cell microarray screening method developed by Juha Rantala, Senior Scientist at VTT. Research with a material impact on cancer drug development was published in Science

New opportunities for personalised cancer medicine

Activation of lipid metabolism is an early event in carcinogenesis and a central hallmark of many cancers. However, the precise molecular composition of lipids in tumours remains generally poorly characterised. Scientists from VTT Technical Research Centre of Finland and the Charité Hospital have found lipids in tumours which are associated with cancer progression.A new study  performed by Matej Orešič and colleagues from the VTT Technical Research Centre of Finland in collaboration with the team of Carsten Denkert (Institute of Pathology,

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