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Having studied the effects of radioisotopes on ovarian cancer, I believe that alpha-emitting radiopharmaceuticals represent a promising new approach for treating patients suffering from advanced ovarian cancer, who have been debulked to no residual tumor. All opportunities to improve the lives of ovarian cancer patients should be explored. Radspherin® has demonstrated compelling preclinical activity in multiple cancer models, and I am looking forward to further investigate it in this phase 1 study.
Professor Ignace Vergote, MD PhD FACS FSPS Chairman, Department of Obstetrics and Gynaecology Gynaecological Oncologist, University Hospital Leuven Belgium and lead clinical investigator
We are pleased that both phase 1 trials are now underway. This is a major milestone for the company. These studies are the first step in the clinical development of Radspherin®, and we expect them to provide important information about safety and distribution of the product candidate in the peritoneal cavity of patients suffering from peritoneal carcinomatosis. With the high unmet need in this underserved patient population and based on our encouraging preclinical data, we hope that Radspherin® may provide ovarian cancer and colorectal cancer patients with better outcomes. We are excited to have started the Phase 1 clinical program and we look forward to working closely with the hospitals and clinical researchers to advance the clinical development of Radspherin® as quickly as possible.
Jan A. Alfheim, Chief Executive Officer of Oncoinvent
Radspherin® represents a promising new approach for treating patients with metastates to the peritoneal cavity from colorectal cancer that may potentially provide a better outcome with longer progression free survival for patients that undergo cytoreductive surgery together with hypertherm intraperitoneal chemotherapy. We are always looking for opportunities to improve patient outcomes and give patients a better quality of life. Radspherin® has demonstrated preclinical activity in a range of cancer models, and we are excited to further investigate it in this Phase 1 study.
Stein Gunnar Larsen, M.D., Section Leader Department of Surgical Oncology, Oslo University Hospital, Norway
Radspherin® is a potentially transformative approach for a range of difficult-to-treat metastatic cancers. The mode of action of Radspherin® is to deliver a lethal dose of short range alpha radiation to remaining tumour cells in the peritoneum after surgery. Radium-224 emits alpha particles with high linear energy transfer (LET). There are no known cellular resistance mechanisms to this type of ionizing radiation, which may therefore be effective against dormant and chemo-resistant cancer cells remaining after surgical resection of macroscopic visible tumours and thereby increase the prospect of a complete response. We believe it could provide a profound benefit for patients that are in dire need of new therapies
Øyvind S. Bruland, M.D., Chief Medical Officer of Oncoinvent
“We are very excited to join forces with Oncoinvent,” said Ingrid Teigland Akay, Managing Partner with Hadean Ventures. “Oncoinvent holds world class expertise within radiopharmaceuticals and is now moving into clinical development with their lead compound to tackle conditions for which patients today have no good treatment options, including peritoneal carcinomatosis. We are looking forward to supporting Oncoinvent on this journey”
Dr. Ingrid Teigland Akay, Managing Partner with Hadean Ventures
“We are pleased to add Hadean Ventures to our list of shareholders,” said Oncoinvent Chief Executive Officer Jan A. Alfheim. “Having the financial support and industry expertise of Hadean Ventures will help us execute our vision even more rapidly and broadly. Furthermore, we are excited about the experience, perspective and relationships that a Nordics focused life science investor such as Dr. Teigland Akay can provide to our board of directors.”
Oncoinvent Chief Executive Officer Jan A. Alfheim
Oncoinvent Board Chair, Dr. Roy H. Larsen commented, “It is satisfying to note that after careful scrutiny of Oncoinvent via a thorough due diligence process, a professional life science fund manager such as Hadean Ventures has decided to make a significant investment in the company. I would like to welcome Dr. Teigland Akay to the Oncoinvent Board of Directors, and I look forward to working with her. “
Oncoinvent Board Chair, Dr. Roy H. Larsen
“We are pleased at the response that we have received from the investment community regarding our private placement. The round was heavily oversubscribed. With this financing round we now have, in addition to the new funding, a shareholder base in the company that will enable Oncoinvent to bring Radspherin™ to a clinical proof of concept.”
Jan A. Alfheim, Oncoinvent’s CEO
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Oncoinvent ASA announces oversubscribed private placement

Oncoinvent ASA ("Oncoinvent" or the "Company") is pleased to announce that it has today successfully completed the bookbuilding process for a private placement of new shares and that gross proceeds of NOK 130 million is being raised by the issuance of 65,000,000 new shares (the "Offer Shares") at a subscription price of NOK 2 per share (the "Private Placement").“We are pleased to announce the successful completion of the private placement with a contemplated subsequent listing on Euronext Growth Oslo. I would like to express my gratitude for shareholders' full support and trust in our

Oncoinvent Announces Promising Interim Results for Radspherin® as a Potential Treatment for Peritoneal Carcinomatoses

Oncoinvent ASA, a clinical stage company advancing alpha emitter therapy across a variety of solid cancers, today announced an interim data readout of the Phase 1/2a studies of Radspherin® for the treatment of peritoneal carcinomatoses. The studies were closed for recruitment at the end of 2023, and patients are currently in long-term follow-up. The readout confirmed the previously published results on efficacy and adds further confidence in the ongoing randomized controlled Phase 2 clinical trial for Radspherin® in patients with ovarian cancer.In the first interim readout from the Phase 1

Oncoinvent Announces First Patient Dosed in its Phase 2 Clinical Trial of Radspherin® in Ovarian Cancer Patients

Oncoinvent, a clinical stage, radiopharmaceutical company developing innovative treatments for solid cancers, today announced that the first patient has been dosed in its Phase 2 study of Radspherin® in patients with peritoneal carcinomatosis from ovarian cancer. Radspherin® is a novel alpha-radiation therapy candidate designed for targeted, local treatment of cancers that have spread to body cavities. The Phase 2 trial is a randomized controlled study designed to assess progression-free survival (PFS) in primary advanced ovarian cancer patients treated with Radspherin® following complete

BioStock: Fast Track designation facilitates development of Oncoinvent’s Radspherin

The FDA has granted Fast Track to Oncoinvent for its radiopharmaceutical Radspherin as a treatment for peritoneal metastases originating from ovarian cancer. This designation will facilitate the candidate’s clinical development, with the next step being a phase IIb trial first in ovarian cancer patients, then in colorectal cancer patients.Read the full article at biostock.se : https://www.biostock.se/en/2024/06/fast-track-designation-facilitates-development-of-oncoinvents-radspherin/ This is a press release from BioStock - Connecting Innovation & Capital.

BioStock: Oncoinvent strengthens board and cash position

Oncoinvent has appointed esteemed industry leaders to its Board of Directors, led by Gillies O’Bryan-Tear as Chairman. Furthermore, the company has completed a private placement round of NOK 71 million, which enables advancement to phase IIb with Radspherin. BioStock reached out to Gillies O’Bryan-Tear for a comment.Read the full article at biostock.se : https://www.biostock.se/en/2024/04/oncoinvent-strengthens-board-and-cash-position/ This is a press release from BioStock - Connecting Innovation & Capital. https://www.biostock.se

Oncoinvent’s CEO to BioStock: “Radiopharmaceuticals has emerged as the hottest space in oncology”

Radiopharmaceuticals is a hot and emerging area that has attracted great interest from big pharma and investors in 2023, with several successful capital raises, IPOs and deals. A Nordic company within the field is Oncoinvent, based in Oslo and with lead candidate Radspherin in clinical development for the treatment of metastases in the peritoneal cavity from ovarian cancer and colorectal cancer.Read the full article at biostock.se : https://www.biostock.se/en/2024/01/oncoinvents-ceo-radiopharmaceuticals-has-emerged-as-the-hottest-space-in-oncology/ This is

BioStock Investor Pitch: Oncoinvent

Oncoinvent’s CEO Anders Månsson visited BioStock’s studio to talk about the development of the radiopharmaceutical Radspherin for peritoneal carcinomatosis. In his presentation, he delves into the results from the phase I/IIa studies with Radspherin and the upcoming clinical development plan. Furthermore, he talks about Oncoinvent as an investment opportunity and the unmet medical need for these cancer patients.Watch Anders Månsson present Oncoinvent at biostock.se : https://www.biostock.se/en/2024/01/biostock-investor-pitch-oncoinvent/ This is a press

BioStock: Oncoinvent gets IND clearance for both lead indications

Oncoinvent has secured IND clearance from the FDA for both of the planned phase IIb clinical trials with Radspherin in patients with peritoneal carcinomatosis from colorectal cancer and ovarian cancer. This marks a milestone allowing Oncoinvent to clinically advance Radspherin and expand to the US landscape. BioStock reached out to CEO Anders Månsson to find out more about the development strategy.Read the full article at biostock.se: https://www.biostock.se/en/2023/11/oncoinvent-gets-ind-clearance-for-both-lead-indications/ This is a press release from BioStock - Connecting

Oncoinvent Announces U.S. FDA Clearance of Investigational New Drug (IND) Application for Radspherin[®] in Ovarian Cancer Patients

Progressing to study Radspherin[®] in the first-line treatment setting for ovarian cancer IND clearance is now obtained for both lead indications for Radspherin[®]Oncoinvent AS, a clinical stage company advancing alpha emitter therapy across a variety of solid cancers, today announced that it has received clearance from the U.S. Food and Drug Administration (FDA) for its Investigational New Drug (IND) application for the phase 2 study for Radspherin® in patients with peritoneal carcinomatosis from ovarian cancer. This represents the second U.S. FDA IND clearance for Radspherin®, as last

Oncoinvent Announces U.S. FDA Clearance of Investigational New Drug (IND) Application for Radspherin® in Colorectal Cancer Patients

This marks the first IND clearance for initiation of Radspherin® clinical trials in the USOncoinvent AS, a clinical stage company advancing alpha emitter therapy across a variety of solid cancers, today announced that it has received clearance from the U.S. Food and Drug Administration (FDA) for its Investigational New Drug (IND) application for the phase 2b study for Radspherin® in patients with peritoneal carcinomatosis from colorectal cancer.   “We are excited to announce the IND clearance for Radspherin® for colorectal cancer patients following the promising indications of safety

BioStock: Oncoinvent’s CEO comments on Q3 and funding plans

The third quarter was a productive period for Oncoinvent, marked by significant milestones in the clinical development of the radiopharmaceutical Radspherin. Among other things, the company showcased clinical data for the candidate at two large congresses. To gear up for phase IIb in 2024, the company is now planning to raise capital. BioStock reached out to CEO Anders Månsson to find out more.Read the full interview with Anders Månsson at biostock.se: https://www.biostock.se/en/2023/10/oncoinvents-ceo-comments-on-q3-and-funding-plans/ This is a press release from BioStock -

BioStock: Oncoinvent in emerging hot spot in oncology

Anders Månsson recently visited BioStock Studio to talk about his new role as CEO of Oncoinvent, a privately held company headquartered in Oslo. The company’s lead candidate is Radspherin, an alpha-radiating radiopharmaceutical developed for the treatment of peritoneal carcinomatosis from colorectal cancer and ovarian cancer. During the interview, Månsson described Radspherin’s mechanism of action and the company’s clinical development plans for the candidate. Furthermore, he shed light on radiopharmaceuticals as an emerging hot spot in oncology attracting great interest from both big pharma

Oncoinvent Announces Advancement of Radspherin[® ]to Second Dose Level Cohort in Ongoing Phase 1 Trial

Safety Monitoring Committee review of first dose-level cohort allows progression of RAD-18-001 study to second dose level cohortOslo 30. November 2020 Oncoinvent AS, a clinical stage radiopharmaceutical company developing novel radioisotope-based therapies, today announced that the trial Safety Monitoring Committee approved the advancement of the study to the second level dose cohort of the company’s first-in-human Phase 1 clinical study of Radspherin[®, ]RAD-18-001, in ovarian cancer patients suffering from peritoneal carcinomatosis. Enrollment in this cohort, where patients will

Oncoinvent Advances Radspherin[®] to Third Dose Level in Ongoing Phase 1 Clinical Trial

Safety review of second dose-level cohort allows study to advance to third cohort of colorectal cancer patients with peritoneal carcinomatosis in Radspherin[®] clinical trial.Oslo 30. October 2020 Oncoinvent AS, a clinical stage radiopharmaceutical company developing novel radioisotope-based therapies announced today that the trial Safety Monitoring Committee overseeing the first-in-human Phase 1 clinical study of Radspherin[®] in colorectal cancer patients suffering from peritoneal carcinomatosis have approved the advancement of the study to the third level dosing cohort.Jan A. Alfheim,

Oncoinvent Advances Radspherin[®] to Second Dose Level in Ongoing Phase 1 Clinical Trial

Safety review of first dose-level cohort allows progression to second cohort of colorectal cancer patients with peritoneal carcinomatosis in Radspherin[®] clinical trial.Oslo 4. September 2020  Oncoinvent AS, a clinical stage radiopharmaceutical company developing novel radioisotope-based therapies announced today that the trial Safety Monitoring Committee overseeing the first-in-human Phase 1 clinical study of Radspherin[®] in colorectal cancer patients suffering from peritoneal carcinomatosis have approved the advancement of the study to the second level dosing cohort. Jan A.

Oncoinvent Announces Dosing of First Patient with Radspherin[® ]in a Second Phase 1 Clinical Trial

Radiopharmaceutical company starts first-in-human trial in a second patient population; ovarian cancer patients suffering from peritoneal carcinomatosisOslo 11. June 2020 Oncoinvent AS, a clinical stage radiopharmaceutical company developing novel radioisotope-based therapies to provide new therapeutic options for cancer patients, today announced that a second phase 1 clinical trial of it’s lead candidate compound Radspherin[® ]has been initiated. The first ovarian cancer patient has been treated with Radspherin[®] at the Radium Hospital in Oslo under the guidance of clinical

Oncoinvent announces result of oversubscribed repair issue

Reference is made to the extraordinary general meeting notice published on 20[th] of May 2020 regarding a repair issue with gross proceeds of up to NOK 9 million directed towards eligible shareholders and company employees (the "Repair Issue"). The Repair Issue consisted of an offer of minimum 1 and maximum 175,000 new shares (each an "Offer Share") in Oncoinvent AS to eligible shareholders and an offer of minimum 1 and maximum 25,000 new shares (each an "Offer Share") in Oncoinvent AS to eligible employees. The subscription period for the Repair Issue ended on 29[th] of May 2020 at 16.30

Oncoinvent Announces Dosing of First Patient with Radspherin[® ]in Phase 1 Clinical Trial

Radiopharmaceutical company starts first-in-human trial in colorectal patients suffering from peritoneal carcinomatosisOncoinvent AS, a clinical stage radiopharmaceutical company developing novel radioisotope-based therapies to provide new therapeutic options for cancer patients, today announced that the first patient has been dosed in the phase 1, first-in-human clinical trial of it’s lead candidate compound Radspherin[®]. “Radspherin[®] represents a promising new approach for treating patients with metastates to the peritoneal cavity from colorectal cancer that may potentially provide

Oncoinvent Secures 40 Million NOK Financing Round Led by Hadean Ventures

Radiopharmaceutical company brings leading Nordic life science investor onboardOncoinvent AS today announced it has completed a 40 million NOK round of financing. Hadean Ventures led the investment round with participation from existing investors CGS Holding AS, Helene Sundt AS, Alpine Capital AS, Artal AS, and Sciencons AS. The investment brings Oncoinvent’s total funding to 268 million NOK and will help the company aggressively pursue clinical development of its lead product candidate Radspherin[®].  Dr. Ingrid Teigland Akay, Managing Partner of Hadean Ventures will join the Oncoinvent

Oncoinvent: Publication of standardization model for activity of radium-224

Oncoinvent announced today that research relating to a radioactivity standard for radium-224 (224Ra) in secular equilibrium has been published in the Journal of Applied Radiation and Isotopes by Oncoinvent research scientist Elisa Napoli and researchers from the National Institute of Standards and Technology (NIST).  This is an important step in the development of Radspherin® as the standard will form the basis for calibration of clinical doses of Radspherin®.Publication Abstract A standard for activity of 224Ra in secular equilibrium with its progeny has been developed, based on triple-

Oncoinvent awarded 4,6 MNOK in Innovation Funding

Oncoinvent is pleased to announce that the Oslo University Hospital and Oncoinvent have each been awarded Innovation Funding to develop Radspherin® as a treatment for colorectal cancer patients suffering from peritoneal carcinomatosis. The two awards make for a combined total of 7,9 million NOK where Oncoinvent will receive 4,6 MNOK and Oslo University Hospital 3,3 MNOK. The Innovation Norway grants will allow Oncoinvent to expand the clinical use of Radspherin®  from the current planned study in ovarian cancer patients and enables the company to carry out phase 1 clinical trials to assess

Oncoinvent receives manufacturing authorization for clinical trial material

Oncoinvent is pleased to announce that it has received a manufacturing authorization (GMP certificate) for production of Radspherin® clinical trial material from the Norwegian Medicine Agency.   Jan A. Alfheim, Oncoinvent CEO commented, “We are very pleased to have accomplished this important milestone in such a short time after the inauguration of our production facility. The approval provides Oncoinvent with the necessary capacity and flexibility with full control over the production of clinical trial material of Radspherin® for the upcoming clinical studies expected to start later

Oncoinvent signs distribution agreement with radiopharmaceutical wholesaler

Oncoinvent has signed an agreement with the Institute of Energy Technology (IFE) for the distribution of Radspherin (investigational medicinal products) to sites and institutions as part of the company’s clinical trial program. “We are very pleased to have the distribution agreement in place as it is a vital part of our infrastructure going forward. The agreement enables us to provide sites and patients participating in the clinical trial program access to Radspherin in a timely and predictable manner without geographical boundaries.” said Jan A. Alfheim, Oncoinvent’s CEO.

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