Betagenon/Baltic Bio announces positive results from a 28 day Phase IIa trial of the first-in-class AMPK activator O304 in Type 2 Diabetics
O304 reduces significantly fasting plasma glucose (FPG) in type 2 diabeticsThe main study results are not yet finalized. Review of the initial data showed that a number of patients who were included based on HbA1c at screening, had FPG below 7 mM or above 13.3 mM at day 1, and that the data analysis of FPG required a post hoc analysis plan.In type 2 diabetic patients on Metformin with FPG >7 mM and < 13.3 mM ( >126 and < 240 mg/dl) at day 1, where FPG >13.3mM defines uncontrolled hyperglycemia, there were statistical significant differences between the treatment groups in the absolute