Cantargia presents preclinical data demonstrating unique treatment effects of nadunolimab on pancreatic cancer stromal cells
Cantargia (Cantargia AB; Nasdaq Stockholm: CANTA) today reported preclinical data for its lead candidate, the IL1RAP-binding antibody nadunolimab (CAN04), further supporting the promising clinical efficacy seen in pancreatic cancer (PDAC) patients. The new results show that nadunolimab reduces PDAC tumor growth through a strong impact on cancer-associated fibroblasts (CAF), a major component of tumor-supporting stromal cells within PDAC tumors. Furthermore, the broad and unique mode-of-action of nadunolimab disrupts crosstalk between PDAC cells and CAF in sharp contrast to blockade of IL-1β