Enhancement of neurotrophic factor signalling may improve memory functions
Treatments targeted to enhance brain neurotrophic factor signalling could improve memory functions in Alzheimer’s disease even though they don’t alter brain amyloid burden, according to recent research from the University of Eastern Finland. The enhancement of brain derived neurotrophic factor (BDNF) signalling alleviated memory impairment in Alzheimer’s mouse models. In addition, the administration of cerebral dopamine neurotrophic factor (CDNF) into brain tissue improved long-term memory in particular. Alzheimer’ disease is the most common cause of dementia, characterised by the