Attana’s technology contributes to increased understanding of E. Coli pathogenesis
In the paper Yang et al shows how interaction between the bacteria and their specific target receptors can be altered. This can enable the future development of effective drugs or vaccines against infection by E. coli K1.The experimental results showed significantly reduced adherence and invasion of the modified bacterial strain compared to the parent strain. Thereby enabling them to avoid fusing with lysosomes in cells. Kinetic interaction studies with Attana Cell™ 200 demonstrated in detail that O-acetylated PSA from the modified bacteria interacted less and weaker with human sialic