Discontinuation of two CRYSTALIZE evidence trials
1 December 2023 Update on CRYSTALIZE evidence trials Discontinuation of STABILIZE-CKD and DIALIZE-Outcomes Phase III trials AstraZeneca has decided to discontinue the STABILIZE-CKD and DIALIZE-Outcomes Phase III evidence trials for Lokelma (sodium zirconium cyclosilicate). The decision was made due to substantially increased enrolment timelines and low event rates, respectively, which made it prohibitive to deliver study results within a timeframe to meaningfully advance clinical practice. STABILIZE-CKD and DIALIZE-Outcomes trials are part of the CRYSTALIZE evidence programme,