Disrupted epithelial barriers as a predictor of severe COVID-19 development
Severe Covid-19 in epithelial barrier disrupted subjectsDavos, 09 July 2023 Disrupted epithelial barriers as a predictor of severe COVID-19 development According to the epithelial barrier theory, disruption of epithelial barriers by environmental and toxic agents triggers microbial dysbiosis, bacterial translocation to subepithelial areas and local or systemic immune/inflammatory response to environmental agents, allergens and microbes. Such events have been implicated in the development of chronic conditions like allergic, autoimmune, and metabolic diseases, such as