New publications in peer-reviewed scientific journals support the potential for OXC-101 as a novel anti-cancer therapy
OXC-101 shows promise in enhancing the effectiveness of immune checkpoint inhibitors. The article published in Oncogenesis by Helleday laboratory, Karolinska Institute, and Oxcia team suggests that the mitotic MTH1 inhibitor OXC-101 (TH1579) has the potential to enhance the effectiveness of immune checkpoint inhibitors (ICI) in cancer treatment. This is achieved by influencing immune checkpoint-related proteins and pathways (1). The researchers discovered that treatment with OXC-101 leads to an increase in PD-L1 expression and inflammatory response in cancer cell lines. This finding may