Circio presents powerful expression data for new generation circVec 2.0 design at the ESGCT 2023 annual meeting
· New circVec 2.0 design boosts protein expression by up to 10-fold vs. circVec 1.0 · Bioinformatic simulation indicates 10-30-fold higher maximum protein expression vs. mRNA-based systems · circVec has the potential to replace mRNA as the preferred expression system for all viral and DNA-based therapeutics in the futureCircio established the first generation circVec 1.0 genetic cassette based on “Nature´s best design” for human circRNA expression. Following rational, targeted optimization of specific sequences and regulatory elements, Circio has been able to further improve the