SynAct Pharma submits clinical trial application for AP1189 in Nephrotic Syndrome
SynAct Pharma AB ("SynAct") today announced that the company has submitted a clinical trial application (CTA) to the Danish Medicines Agency to initiate a Phase IIa study with its lead candidate drug AP1189 in Idiopathic Membranous Nephropathy (IMN). IMN is the single most common cause of Nephrotic Syndrome in adults.In the Phase IIa study, AP1189 will be tested in a double-blind, placebo-controlled multicenter study as add-on therapy to ACE-inh or A2R-ant treatment in a once-daily dose regimen for four weeks with the primary endpoint to show treatment effect on urinary protein excretion