More efficient drug delivery within the brain by utilizing LAT1
University of Eastern Finland Press release, 24 September 2019According to a new study carried out at the University of Eastern Finland, the distribution of drug molecules within the brain can be improved by utilizing LAT1, which is expressed highly in the brain. By converting drug molecules temporarily into prodrugs, derivatives that can utilize LAT1 for cell entry and subsequently release the active parent drug within the target cells. This way one can achieve many times higher concentrations compared to the treatment with the parent drugs alone, which cannot utilize LAT1. This is very