Cantargia reports preclinical data highlighting advantages of nadunolimab mechanism of action
Cantargia AB today report new preclinical data on the antibody nadunolimab (CAN04) in combination with the chemotherapy docetaxel. CAN04 increased the anti-tumor effect of docetaxel, but notably, this was not achieved by blocking only one of the pathways targeted by CAN04, using an antibody against IL-1β signaling. Additionally, docetaxel and other chemotherapies induce the release of the other form of IL-1, IL-1α, by tumor cells. These data highlight the potential of CAN04, which blocks both IL-1α and IL-1β, to increase chemotherapy efficacy. CAN04 is entering clinical development in