A step closer to understanding fertilisation
Researchers at Karolinska Institutet in Sweden have taken a step closer to understanding the mechanism that leads to the fusion of egg and sperm at fertilisation. Using the technique X-ray crystallography, they have determined the 3D structure of Juno, a mammalian egg protein essential for triggering gamete fusion. Their findings are not only interesting from an evolutionary perspective, but also reveal the shape of a possible target for future non-hormonal contraceptives.The fusion of egg and sperm is an essential step of fertilisation in sexually reproducing organisms and the molecular