New therapeutic principle for Parkinsonian dyskinesia shows clinical effect
Involuntary dyskinetic movements induced by treatment with levodopa (L-dopa) are a common problem for people with Parkinson’s disease. Now, however, researchers at Karolinska Institutet and Lund University in Sweden seem to be close to a novel therapy to this distressing side effect. A treatment study published in the scientific periodical Brain shows that a drug that stimulates certain serotonin receptors in the brain counteracts the dyskinesia causing effects of L-dopa.The substance tested by the team, eltoprazine, is a so-called serotonin receptor agonist that targets receptor types 5-